Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo - PubMed

This study suggests that AST has a dose-dependent ocular anti-inflammatory effect, by the suppression of NO, PGE2, and TNF-alpha production, through directly blocking NOS enzyme activity.分類：pmid:12766075, doi:10.1167/iovs.02-0822, Comparative Study, Research Support, Non-U.S. Gov't, Kazuhiro Ohgami, Kenji Shiratori, Shigeaki Ohno, Animals, Antioxidants / pharmacology*, Aqueous Humor / metabolism, Cell Count, Cell Line, Cell Survival, Dinoprostone / biosynthesis, Dose-Response Relationship, Drug, Lipopolysaccharides / toxicity*, Macrophages / drug effects, Macrophages / metabolism, Male, Nitric Oxide / biosynthesis, Nitric Oxide Synthase / antagonists & inhibitors, Nitric Oxide Synthase / metabolism, Nitric Oxide Synthase Type II, Prednisolone / pharmacology, Rats, Rats, Inbred Lew, Salmonella typhimurium*, Tumor Necrosis Factor-alpha / biosynthesis, Uveitis, Anterior / chemically induced, Uveitis, Anterior / metabolism, Uveitis, Anterior / prevention & control*, Xanthophylls, beta Carotene / analogs & derivatives*, beta Carotene / pharmacology*, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE...