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Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium - PubMed

Low molecular weight hyaluronan enhances or induces inflammation through toll-like receptor 4 (TLR-4). However, the effects of high molecular weight hyaluronan (HA900) on TLR-4 are unknown. In this study, HA900 (900 kDa) was administered orally to MRL-lpr/lpr mice, a Th-1-type autoimmune disease mod …分類:pmid:20504769, PMC2915711, doi:10.1074/jbc.M110.104950, Akira Asari, Tomoyuki Kanemitsu, Hitoshi Kurihara, Administration, Oral, Animals, Female, Gene Expression Regulation*, Humans, Hyaluronic Acid / administration & dosage*, Hyaluronic Acid / chemistry, Immune System*, Intestinal Mucosa / cytology*, Mice, Mice, Transgenic, Oligonucleotide Array Sequence Analysis, Suppressor of Cytokine Signaling 3 Protein, Suppressor of Cytokine Signaling Proteins / metabolism, Toll-Like Receptor 4 / metabolism*, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE...

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