Salmon nasal cartilage proteoglycan enhances growth of normal human dermal fibroblast through Erk1/2 phosphorylation - PubMed

Proteoglycan (PG) is a heavily glycosylated protein, localized to cell surface and extracellular matrix, and has various functions. Recently, it has been gradually revealed that PG interacts with various growth factors and morphogens and regulates cellular functions. Although salmon nasal cartilage …分類：pmid:28463592, doi:10.1080/09168451.2017.1318695, Masahiro Sano, Yi Shang, Tomoaki Saito, Animals, Cell Proliferation / drug effects, Cells, Cultured, Dermis / cytology, Dermis / drug effects*, Dermis / enzymology, Dose-Response Relationship, Drug, Enzyme Activation / drug effects, Fibroblasts / cytology, Fibroblasts / drug effects*, Fibroblasts / enzymology, Flavonoids / pharmacology, Gene Expression Profiling, Gene Expression Regulation, Humans, Microarray Analysis, Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors, Mitogen-Activated Protein Kinase 1 / genetics*, Mitogen-Activated Protein Kinase 1 / metabolism, Mitogen-Activated Protein Kinase 3 / antagonists & inhibitors, Mitogen-Activated Protein Kinase 3 / genetics*, Mitogen-Activated Protein Kinase 3 / metabolism, Nasal Cartilages / chemistry*, Phosphorylation / drug effects, Protein Kinase Inhibitors / pharmacology, Proteoglycans / isolation & purification, Proteoglycans / pharmacology*, Salmon, Signal Transduction, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE...