Aerobic exercise induces tumor suppressor p16INK4a expression of endothelial progenitor cells in human skeletal muscle - PubMed

Aerobic exercise induces oxidative stress and DNA damage, nevertheless, lowers cancer incidence. It remains unclear how genetic stability is maintained under this condition. Here, we examined the dynamic change of the tumor suppressor p16INK4a in cells of skeletal muscle among young men f …分類：pmid:33104519, PMC7655215, doi:10.18632/aging.103763, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Jinfu Wu, I-Shiung Cheng, Chia-Hua Kuo, Antigens, CD / metabolism, Antigens, Differentiation, Myelomonocytic / metabolism, Bicycling, CD163 Antigen, Cross-Over Studies, Cyclin-Dependent Kinase Inhibitor p16 / genetics, Cyclin-Dependent Kinase Inhibitor p16 / metabolism*, DNA Damage, Down-Regulation, Endothelial Progenitor Cells / drug effects, Endothelial Progenitor Cells / metabolism*, Endothelial Progenitor Cells / pathology, Exercise*, Ginsenosides / administration & dosage, Humans, Interleukin-10 / genetics, Interleukin-10 / metabolism, Macrophages / drug effects, Macrophages / metabolism, Male, Muscle Contraction*, Necrosis, Oxidative Stress, Oxygen Consumption, Quadriceps Muscle / drug effects, Quadriceps Muscle / metabolism*, Quadriceps Muscle / pathology, Receptors, Cell Surface / metabolism, Time Factors, Vascular Endothelial Growth Factor A / genetics, Vascular Endothelial Growth Factor A / metabolism, Young Adult, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE...